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产品目录

重组大鼠IL-13,113a.a.图片
产品货号:
GS4859
中文名称:
重组大鼠IL-13,113a.a.
英文名称:
Recombinant Rat Interleukin-13, 113a.a.
产品规格:
2μg
发货周期:
1~3天
产品价格:
询价
分子量:Approximately 12.3kDa,a single non-glycosylated polypeptide chain containing 113 amino acids.
储存条件:冷冻(-20℃)

概述

Interleukin-13(IL-13)is expressed by the IL13 gene and secreted by many cell types,especially T helper type 2(Th2)cells.The high solution from of IL-13 reported to be a monomer with two internal disulfide bonds that contribute to a bundled four α-helix configuration.Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites.IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1beta,TNF-alpha,IL-6 and IL-8.IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE.Mature rat IL-13 shares 59%,75%,and 60%amino acid sequence identity with human,mouse,and rhesus IL-13,respectively.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格

外观Sterile Filtered White lyophilized(freeze-dried)powder.
纯度>98%by SDS-PAGE and HPLC analyses.
来源Escherichia coli.
生物活性Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 5ng/ml,corresponding to a specific activity of>2.0×105 IU/mg.
成分Lyophilized from a 0.2μmfiltered concentrated solution in 2×PBS,pH 7.4,5%trehalose.
内毒素Less than 1 EU/μg of rRtIL-13,113a.a.as determined by LAL method.
复溶We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/ml.Stock solutions should be apportioned into working aliquots and stored at ≤ -20?C.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列TPGPVRRSTS PPVALRELIE ELSNITQDQK TSLCNSSMVW SVDLTAGGFC AALESLTNIS SCNAIHRTQR ILNGLCNQKA SDVASSPPDT KIEVAQFISK LLNYSKQLFR YGH

相关搜索:重组大鼠IL-13,113a.a.IL-13, 113a.a., RatRecombinant Rat Interleukin-13, 113a.a.
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